Around 60 firefighters have brought a major blaze under control at Nottingham University.
The "significant incident" began at approximately 8.30pm on Friday at the GlaxoSmithKline building on the Jubilee Campus.
Witnesses said they have heard loud explosions from the building, which is under construction and unoccupied.
No one was injured and no other buildings were affected as fire crews fought to gain control of the fire while it tore through the timber-framed building, sending burning debris into the sky above.
Nottingham Fire and Rescue group manager Joanne Wooler-Ward said: "No other buildings have been affected, fortunately no people were involved in this fire and we've had 12 crews here, that's over 60 firefighters.
Smoke has been billowing from the university campus. Pic: Sam Bradley "Credit to those firefighters who pulled out all the stops to prevent this fire spreading.
"When we arrived, the fire was a significant size - it could be seen from quite a distance - and there was a smoke plume spreading towards the campus area so we sent out a message for people to keep doors and windows closed.
"The firefighters have worked hard to contain that fire and stop it from spreading to any other buildings."
The building is under construction and is unoccupied. Pic: Sarah Armes In a statement, university registrar Dr Paul Greatrix said: "Thankfully, there have been no casualties as this is a building that was still under construction."
The carbon-neutral building, which was due to be opened early next year, cost £15.8m and would have had enough laboratory space for more than 100 researchers.
Some eyewitnesses on Twitter have claimed that the complex has been "completely destroyed".
Dr Greatrix added: "(Saturday) we are due to welcome prospective students and their families to Nottingham for our Open Day and we would like to stress that this is still going ahead as planned."
A woman saves a dog from the fire. Pic: @manchesterfire
Mr Ballance says he will never forget what happened
Firefighters said 150 dogs were rescued. Pic: Manchester Fire
The dogs' home was established in 1893. Pic: @StacyHilton
Shoppers were warned that independence could mean higher prices
RBS will be moving its headquarters to London if there is a Yes vote
Yes campaign leader Alex Salmond demanded an investigation into a leak
John Prescott meets voters in Scotland
David Cameron has hit the campaign trail in Scotland
The latest poll shows Alex Salmond's Yes campaign is lagging behind again
The referendum takes place on September 18
Keith Vaz MP, chairman of Commons Home Affairs Select Committee
Former South Yorkshire chief constable Meredydd John Hughes
David Crompton admits things should have been done differently
Ashya has been ruled fit to travel to Prague by the courts
Divers and sniffer dogs have been searching the River Brent
Police want to speak to cyclists seen near Alice before she disappeared
The teenager has not been seen since August 28
Alice was spotted on CCTV before she vanished
A social media campaign was launched after the 14-year-old went missing